Combinations ; See Below
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Retrovir | GlaxoSmithkline | Surgipharm Ltd | 100mg | 100 | Capsule | per capsule | KES 2,938.00 |
| Retrovir | GlaxoSmithkline | Surgipharm Ltd | 300mg | 60 | Tablet | per tablet | KES 3,370.92 |
| Retrovir | GlaxoSmithkline | Surgipharm Ltd | 50mg | 200ml | Syrup | per 5ML | KES 3,832.30 |
| Zido-H | Hetero Drugs Ltd | Unisel Pharma (K) Ltd. | 300mg | 60 | Capsule | per capsule | KES 1,203.00 |
| Zidocos | Cosmos Limited. | Cosmos Limited | 100mg | 100 | Tablet | per tablet | KES 760.00 |
| Zidocos | Cosmos Limited. | Cosmos Limited | 300mg | 60 | Tablet | per tablet | KES 1,100.00 |
| Zidovir | Cipla Ltd. | Surgipharm Ltd | 100mg | 10 | Capsule | per capsule | KES 670.00 |
| Zidovir | Cipla Ltd. | Surgipharm Ltd | 300mg | 60 | Tablet | per tablet | KES 1,030.00 |
| Zidovir | Cipla Ltd. | Surgipharm Ltd | 50mg | 200ml | Syrup | per 5ML |
| Zidovudine (AZT) More info | |
|---|---|
| Mode Of Action | Nucleoside reverse transcriptase inhibitors (NRTIs) that are converted by cellular cells? enzymes to active phosporylated metabolites that inhibit viral reverse transcriptase and viral DNA synthesis. |
| Drug Indication | HIV in adults and children with progressive or advance immunodeficiency. (T-helper cell counts of less than 500/mm3). Used in combination with other ARVs. |
| Precautions | Hepatic and renal impairment, 1st trimester of pregnancy, avoid in lactation, monitor haematological parameters. |
| Side Effects | Anaemia (sometimes fever), haematological disorders like neutropenia, malaise, nausea, vomiting, anorexia, headache, insomnia, abdominal pains, myalgia. |
| Dosage | Asymptomatic disease - initially 500mg to be increased as the disease progresses to 1.5g daily. Symptomatic disease 200mg every 4hrs. If tolerance is poor - 100mg every six hours. Children over 3months -180mg/m2 every 6hrs. I.V inf. - 2.5mg/kg every 4 hrs (for less than 2 weeks. |
| Pregnancy Category | Category B3 |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Studies in animals show evidence of an increased occurrence of foetal damage, the significance of which is uncertain in human |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Hiv Chemotherapy |